The comparison included both the total dose given, frequency, and single vs. Aminoglycosides have long been one of the commonest causes of drug induced nephrotoxicity. The most commonly utilized parenteral agents in this class include gentamicin, tobramycin and amikacin. Injection route solution therapy has been associated with potential neurotoxicity, ototoxicity, and nephrotoxicity. Extract against gentamicininduced nephrotoxicity in rats moustafa m. Structural latency of lysosomal nacetyl3glucosaminidasefollowing gentamicin treatment mean of four independent experiments sem. Administration of gentamicin to rabbits intramuscularly at a dose of 80 mgkg per day for 5 days induced nephrotoxicity exhibited by significantly p g entamicin is an important bactericidal antibiotic with two serious potential adverse effects. Cytochrome p 450 is one enzyme that involved in acute renal failure. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity. Dailymed gentamicin gentamicin sulfate injection, solution. Gentamicin sulfate equivalent to 40 mg gentamicin, methylparaben 1. Recent data has shown metformin to possess antioxidant activity.
In the current study a dose of 80 mgkg gentamicin was given daily to male rats for one week. Sweileh clinical pharmacology, annajah national university, nablus, palestine introduction aminoglycosides are commonly used in everyday clinical practice for the treatment of gramnegative infections 1. Hydroalcohalic extract of ficus carica hefc retard the progression of certain types of cancers, cardiovascular and renal disorders. Esterhai jl, bednar j, kimmelman cp gentamicin induced ototoxicity complicating treatment of chronic osteomyelitis. Neurotoxicity manifested by ototoxicity, both vestibular and auditory, can occur in patients treated with gentamicin, primarily in those with preexisting renal damage and in patients with normal renal. Influence of iron, deferoxamine and ascorbic acid on gentamicininduced nephrotoxicity in rats. However, many do not know that, contrary to textbooks and antibiotic guidelines, gentamicin ototoxicity causes impairment of vestibular. India abstract gentamicin gm induced nephrotoxicity limits its longterm clinical use. There have been several factors previously reported as increasing the risk of nephrotoxicity. Administration of gentamicin to rabbits intramuscularly at a dose of 80 mgkg per day for 5 days induced nephrotoxicity exhibited by significantly p gentamicin has also been isolated that retains clinical efficacy, but does not cause nephrotoxicity. Until these interventions become adopted in clinical practice, however, clinicians must utilize established strategies to reduce the incidence of aminoglycoside induced nephrotoxicity.
Experimental gentamicin nephrotoxicity and agents that modify it. Although a clear recognition of the patient and treatmentrelated risk factors, combined with the onceaday schedule and effective monitoring procedures, have definitely improved the situation over what prevailed in the early 1980s, we are still short of having brought the safety of. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Although aminoglycosideinduced nephrotoxicity has been the subject of multiple studies, the short and longterm effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined. This article is from iranian journal of basic medical sciences, volume 16. Several agentsstrategies were attempted to prevent gm nephrotoxicity but were not found suitable for clinical practice. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. Mar 31, 2015 evaluation seminar on molecular mechanisms of drug induced nephrotoxicity. Borade department of pharmacology, rajgad dnyanpeeths college of pharmacy, bhor, m.
Gentamicin induced oxidative stress plays an important role in this nephrotoxicity. Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious gramnegative infections. The impact of gender as a risk factor for aminoglycoside induced nephrotoxicity. Adverse effects 1, 2 hypomagnesaemia, hypocalcaemia, hypokalaemia. Aminoglycosides have long been one of the commonest causes of druginduced nephrotoxicity. Clinicians are well aware that rising serum creatinine levels in patients treated with gentamicin could indicate nephrotoxicity. The protection against gentamicin nephrotoxicity in the streptozotocininduced diabetic rat. Qadir and others published gentamicin induced nephrotoxicity in albino mice. A prospective comparative study of gentamicin and amikacin induced nephrotoxicity in patients with normal baseline renal function waleed m. This work was conducted to evaluate the possible renoprotective effect of eryngium caucasicum against gentamicin induced renotoxicity.
Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Nephrotoxicity due to a aminoglycosides b cyclophosphamide c cisplatin d radiocontrast e analgesic f amphotericin g crystal. Calcium dobesilate for prevention of gentamicininduced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction. Identification of genes involved in gentamicin induced. Dec 27, 2019 rougier f, claude d, maurin m, maire p.
Effect of methanolic extract of hibiscus plantinifolius leaves on serum and urine electrolytes in gentamicin induced nephrotoxicity. Gentamicin and amikacininduced nephrotoxicity was compared based on scr levels figures 1 and 2. Cimetidine appears to have protective effect on gentamicinlosartaninduced nephrotoxicity in rats. Cimetidine appears to have protective effect on gentamicin losartan induced nephrotoxicity in rats. Identification of genes involved in gentamicin induced nephrotoxicity. Twentyeight male wister rats were divided randomly into 4 equal. Blood urea nitrogen bun and serum creatinine are reported to increase significantly in gentamicin 10 induced nephrotoxicity. Protective effect of alphalinolenic acid on gentamicin. Nephrotoxic effects of aminoglycosides on the developing kidney. Sodium hydroxide andor sulfuric acid may have been added for ph adjustment. Protective effect of metformin against gentamicin induced. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicininduced nephrotoxicity. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity. Gentamicin gminduced nephrotoxicity limits its longterm clinical use.
Nephrotoxicity induced by gentamicin represents a complex. Complete protection from gentamicininduced acute renal failure in the diabetes mellitus rat. Effect of chrysin on gentamicininduced nephrotoxicity in. Extract against gentamicin induced nephrotoxicity in rats moustafa m. Effect of high dietary cholesterol on gentamicininduced. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Aminoglycosides are among the oldest antibiotics available to treat serious infections caused by primarily, gramnegative bacteria.
Protective effect of alphalinolenic acid on gentamicin induced nephrotoxicity in mice 1 h. Gentamicininduced nephrotoxicity 585 gentamicin for 8 days, mgkg fig. Here, we studied the effect of aqueous saffron extract on gentamicin toxicity. Plajer sm, chin pk, vellabrincat jw, buffery pj, begg ej. Nephrotoxicity due to a aminoglycosides b cyclophosphamide c cisplatin d radiocontrast e analgesic f. A number of crude herbal extracts have been reported to ameliorate gentamicininduced nephrotoxicity. Olive leaf extract ole has been demonstrated to have antioxidant and antiinflammatory.
Nephrotoxicity was induced in male spraguedawley rats 220250 g by intraperitoneal administration of gentamicin 120 mg kgg 1 for 7 consecutive days. The risk of nephrotoxicity is greater in patients with impaired renal function and in those who receive high dosage of prolonged therapy. Effect of cimetidine on gentamicinlosartan induced. Does propylthiouracil increase the gentamicininduced. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicininduced nephrotoxicity in rats. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. Treatment of experimental animals with gentamicin results in apoptosis23. Protective effect of apocynin against gentamicininduced.
Risk of aki with gentamicin as surgical prophylaxis. Table ii shows the baseline clinical and demographic characteristics of the gm and ak groups. In culture, gentamicin also causes both apoptosis 27 and necrosis of these cells. Saffron extract has been previously used to decrease oxidative stress induced by ischemiareperfusion.
Patients with impaired renal function, advanced age, dehydration, and those who receive high doses or prolonged therapy are at an increased risk of toxicity. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Pdf how to prevent, recognize, and treat druginduced. What is the evidence of safety of gentamycin use in children. In this study, the protective effect of hydroalcoholic extract of lavandula officinalis on gentamicininduced nephrotoxicity was studied. However, significant differences in gender susceptibility were observed with ak induced nephrotoxicity 31.
This is a pdf file of an unedited manuscript that has been accepted for publication. The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gminduced nephrotoxicity in male rats. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. Nephroprotective effect of aqueous extract of pimpinella anisum in. Aminoglycoside nephrotoxicity kidney international. Effect of cyclooxygenase inhibitors on gentamicininduced. Gentamicin cytotoxicity occurs in those cell types in which the drug accumulates. Gentamicin injection is a sterile, nonpyrogenic aqueous solution for parenteral administration. However, its usefulness is limited by its nephrotoxicity. Conclusion pretreatment with normobaric hyperoxia and daily oxygen therapy improved gentamicin nephrotoxicity possibly via inhibition of lipid peroxidation and increasing the renal catalase activity but could not restore any parameter at the same levels as control group. The cessation of the treatment allows a recovery to control values within approximately 8 days. Although aminoglycoside induced nephrotoxicity has been the subject of multiple studies, the short and longterm effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined.
Aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. Inhibitory effect of olive leaf extract on gentamicin induced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. Nephrotoxic effects of aminoglycosides on the developing. Extracts at the doses 200 and 400 mgkgday for 10 consecutive days, by intraperitoneal route i. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of reactive oxygen species. Histopathologic and biochemical study of the effect of. Risk factors and comparisons of clinical nephrotoxicity of aminoglycosides. Protective role of hydroalcoholic extract of ficus carica in. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27.
Gouvea w, vaamonde cm, owens b, alpert h, pardo v, vaamonde ca. Monitor renal and auditory function during therapy and discontinue therapy or adjust dose if. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicinadministered rats. Esterhai jl, bednar j, kimmelman cp gentamicininduced ototoxicity complicating treatment of chronic osteomyelitis. Twentyeight male wister rats were divided randomly into 4. Protective effect of hydroalcoholic extract of lavandula. Although the exact mechanism of gentamicininduced nephrotoxicity is not well understood, numerous studies have found different pathways involved in this. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of. Gentamicin gm induced nephrotoxicity limits its longterm clinical use. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Inhibitory effect of olive leaf extract on gentamicininduced. Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections.
Inhibitory effect of olive leaf extract on gentamicininduced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. Sildenafil, a selective phosphodiesterase5 inhibitor, was reported to prevent or decrease tissue injury. Finally, there is evidence for oxidative stress in gentamicininduced nephrotoxicity. Gentamicin is inactivated by solutions containing penicillins. Inhibitory effect of olive leaf extract on gentamicin. In this experimental study, thirty wistar male rats were divided randomly into five groups of six in each group. Nov 21, 2016 gentamicin injection is a sterile, nonpyrogenic aqueous solution for parenteral administration.
Gentamicin is used against gram negative infections, but major problem encountered is nephrotoxicity that occurs in 1020% of therapeutic regimes. Effect of normobaric hyperoxia on gentamicininduced. Abdelhamid department of pharmacology, and department of pathology faculty of medicine, assiut university abstract gentamicin gent which is a commonly used antibiotic causes nephrotoxicity in man and animals. Numerous factors are known to be associated with aminoglycoside nephrotoxicity, such as age, renal function, and frequency of dosing 35. Calcium dobesilate for prevention of gentamicininduced. Nephroprotection of withania somnifera root extract against gentamicin induced nephrotoxicity. The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gm induced nephrotoxicity in male rats. In the kidneys, these cells constitute the epithelial cells in the cortex, mainly in the proximal tubule of experimental animals 37 and humans, 16 and also in the distal and collecting ducts. The aminoglycoside antibiotic gentamicin gm is still widely used against infections by grampositive and.
Pioglitazone attenuates kidney injury in an experimental model of. Gentamicin induced nephrotoxicity 585 gentamicin for 8 days, mgkg fig. Sildenafil ameliorates gentamicininduced nephrotoxicity. Current clinical pharmacology, 229232 229 gender differences. Rats were either treated with chrysin 10, 20 and 40 mg kgg 1, p. Protective role of hydroalcoholic extract of ficus carica. Sep 07, 2014 aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads.
A prospective comparative study of gentamicin and amikacin. Pimpinella anisum mitigated the severity of gentamicininduced renal damage. Influence of iron, deferoxamine and ascorbic acid on gentamicin induced nephrotoxicity in rats. Although the rates of aki we observed are similar to other reported rates of gentamicin nephrotoxicity, 1,2,5,1012 it is clear that these rates are higher than in some studies, which in part may be due to differing definitions of nephrotoxicity. The frequent use of nonsteroidal antiinflammatory drugs nsaid in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Male and female patients on ak were also comparable in demographic and clinical characteristics. Aminoglycoside antibiotic, gentamicin, is widely used against gramnegative bacteria. Aminoglycoside induced renal phospholipidosis and nephrotoxicity. A central aspect of aminoglycoside nephrotoxicity is their tubular cytotoxicity. Previously we studied the hydrogen peroxide scavenging activity of eryngium caucasicum.
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